Sainte-Rose Christian, Puget Stéphanie, Wray Alison, Zerah Michel, Grill Jacques, Brauner Raja, Boddaert Nathalie, Pierre-Kahn Alain
Service de Neurochirurgie Pédiatrique, Hôpital Necker Enfants Malades, 149 rue de Sèvres, 75015, Paris, France.
Childs Nerv Syst. 2005 Aug;21(8-9):691-5. doi: 10.1007/s00381-005-1209-2. Epub 2005 Aug 3.
For a long time, craniopharyngiomas have been considered surgically attractive tumours. The fact that they are rare, histologically benign, and located in a challenging (but considered accessible) area made them worthy surgical prizes.
As we have saved vision and "cured" many of these tumours, the insidious and devastating effects on quality of life for these children has become evident.
The state-of-the-art in the surgical management of craniopharyngioma is now turning to multi-modality treatment strategies (combination surgery and radiotherapy) aiming to limit morbidity. Questions remain-what factors influence our surgical decision making? Do we understand the long-term effects of the radiotherapy now being employed? We review a series of craniopharyngiomas looking for variables that correlated with outcome as perceived in terms of quality of life and we review briefly the history of craniopharyngioma surgery and the relevant literature.
长期以来，颅咽管瘤一直被视为具有手术吸引力的肿瘤。它们罕见、组织学上为良性且位于具有挑战性（但被认为可接近）的区域，这一事实使它们成为值得争取的手术目标。
由于我们挽救了视力并“治愈”了许多此类肿瘤，这些肿瘤对儿童生活质量的潜在且严重的影响已变得明显。
颅咽管瘤手术管理的最新技术目前正转向旨在限制发病率的多模式治疗策略（手术与放疗相结合）。问题依然存在——哪些因素影响我们的手术决策？我们是否了解目前所采用放疗的长期影响？我们回顾了一系列颅咽管瘤，寻找与生活质量方面所感知的结果相关的变量，并简要回顾了颅咽管瘤手术的历史及相关文献。
