Peretz Chava, Alexander Bruce H, Nagahama Sonia I, Domino Karen B, Checkoway Harvey
Sackler Faculty of Medicine, School of Health Professionals, Tel Aviv University, Tel Aviv, Israel.
Mov Disord. 2005 Dec;20(12):1614-7. doi: 10.1002/mds.20606.
Clusters of Parkinson's disease (PD) among healthcare professionals have been interpreted as evidence of an infectious etiology. Anesthetic gases have also been associated with parkinsonism symptoms and PD among patients undergoing general anesthesia. We investigated PD mortality among large cohorts of male U.S. anesthesiologists (n = 33,040) and internal medicine physicians (n = 33,044). PD mortality for any mention on a death certificate was lower than rates in U.S. men during 1979-1995 for both groups, although anesthesiologists had a significantly elevated risk for PD as underlying cause of death for 10-year follow-up. Direct comparisons of mortality between the two cohorts indicated excess PD mortality in anesthesiologists for >10-year follow-up for any mention and for underlying cause of death. These findings lend some support to the hypothesis that infectious agents or anesthetic gases may be associated etiologically with PD.
医疗保健专业人员中帕金森病（PD）的聚集现象被解释为感染性病因的证据。麻醉气体也与全身麻醉患者的帕金森综合征症状和帕金森病有关。我们调查了大批美国男性麻醉医师（n = 33,040）和内科医师（n = 33,044）中的帕金森病死亡率。1979 - 1995年期间，两组中死亡证明上任何提及帕金森病的死亡率均低于美国男性的死亡率，尽管在10年随访中，麻醉医师作为潜在死因患帕金森病的风险显著升高。两组队列之间死亡率的直接比较表明，在超过10年的随访中，麻醉医师因任何提及的帕金森病和潜在死因导致的帕金森病死亡率过高。这些发现为感染因子或麻醉气体在病因上可能与帕金森病有关的假说提供了一些支持。
