Logroscino Giancarlo, Chen Honglei, Wing Al, Ascherio Alberto
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
Mov Disord. 2006 Jun;21(6):835-8. doi: 10.1002/mds.20826.
Iron overload and systemic iron stores may be important in the pathogenesis of Parkinson's disease (PD). We therefore examined the association between blood donations, which reduce body iron stores, and risk of PD in the Health Professionals Follow-Up Study, a large cohort investigation of U.S. men. Our hypothesis was that blood donation reduces the risk of PD by lowering systemic iron stores. Although the number of blood donations was inversely related to the ferritin levels in a subsample of the study population, no association was found between the number of blood donations and risk of PD (P for trend = 0.6). Unexpectedly, the risk of PD was higher among men who reported recent multiple blood donations (P for trend = 0.05). The results of this study do not support the hypothesis that reduced systemic iron stores lower the risk of PD.
铁过载和全身铁储备可能在帕金森病（PD）的发病机制中起重要作用。因此，在针对美国男性的大型队列研究“健康专业人员随访研究”中，我们研究了可减少体内铁储备的献血与患PD风险之间的关联。我们的假设是，献血通过降低全身铁储备来降低患PD的风险。尽管在研究人群的一个子样本中，献血次数与铁蛋白水平呈负相关，但未发现献血次数与患PD风险之间存在关联（趋势P值 = 0.6）。出乎意料的是，报告近期多次献血的男性患PD的风险更高（趋势P值 = 0.05）。本研究结果不支持全身铁储备减少会降低患PD风险这一假设。
