Gokden Murat, Shinde Anjali
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA.
Diagn Cytopathol. 2005 Sep;33(3):166-72. doi: 10.1002/dc.20345.
Differential diagnosis of primary and metastatic carcinomas of the liver can be problematic and may require immunohistochemical work-up. Recently, new immunohistochemical markers have been introduced with promising results in this area. We studied three of these markers, human hepatocyte antibody (HepPar-1), human epithelial-related antigen (MOC-31), and thyroid transcription factor-1 (TTF-1), in cell-block sections of fine-needle aspirations from 30 hepatocellular carcinomas and 27 metastatic carcinomas from various sites. Of 27 metastatic carcinomas, all but one were positive for MOC-31 and, all but one were negative for HepPar-1. TTF-1 was positive only in the nuclei of metastatic poorly differentiated neuroendocrine carcinoma from the lung. Of 30 hepatocellular carcinomas, 26 were positive for HepPar-1 and all were negative for MOC-31, while TTF-1 showed cytoplasmic staining in 23 cases. HepPar-1, MOC-31, and TTF-1 are complementary markers in the differential diagnosis of primary and metastatic carcinomas of the liver, with high sensitivity and specificity.
肝脏原发性癌和转移性癌的鉴别诊断可能存在问题，可能需要进行免疫组化检查。最近，有新的免疫组化标志物被引入，在这一领域取得了有前景的结果。我们在30例肝细胞癌以及27例来自不同部位的转移性癌的细针穿刺细胞块切片中研究了其中三种标志物，即人肝细胞抗体（HepPar-1）、人上皮相关抗原（MOC-31）和甲状腺转录因子-1（TTF-1）。在27例转移性癌中，除1例以外其余所有病例MOC-31均呈阳性，除1例以外其余所有病例HepPar-1均呈阴性。TTF-1仅在肺转移性低分化神经内分泌癌的细胞核中呈阳性。在30例肝细胞癌中，26例HepPar-1呈阳性，所有病例MOC-31均呈阴性，而23例病例TTF-1呈胞质染色。HepPar-1、MOC-31和TTF-1是肝脏原发性癌和转移性癌鉴别诊断中的互补标志物，具有高敏感性和特异性。
