Arriaga Francisco, Llopis Francisco, de la Rubia Javier, Carpio Nelly, Moscardó Jesús, Marty María L
Department of Hematology, University Hospital La Fe, Valencia, Spain.
Transfusion. 2005 Aug;45(8):1324-6. doi: 10.1111/j.1537-2995.2005.00196.x.
This study reports the incidence of Wr(a) antigen and anti-Wr(a) in Valencia, Spain.
The incidence of the Wr(a) antigen in 110,000 healthy blood donors was estimated. Likewise, the incidence of anti-Wr(a) was analyzed in a population consisting of 730 healthy blood donors, 356 pregnant women, and 581 patients who received transfusions from the area of Valencia, Spain.
The incidence of Wr(a) antigen was 1 in 785. Overall, anti-Wr(a) was found in 59 samples: 20 healthy blood donors (1/37), 18 pregnant women (1/20), and 21 patients who received transfusions (1/28). The most frequent immunoglobulin class of anti-Wr(a) in healthy blood donors was immunoglobulin M, either alone (8 cases) or plus immunoglobulin G (IgG; 8 cases); the IgG1 and IgG3 were the IgG subclasses most frequently detected in pregnant women (12 cases) and in patients who received transfusions (12 cases). Only 51 percent of the anti-Wr(a) appeared to have the potential to be clinically significant.
These data show that the incidence of Wr(a) antigen and anti-Wr(a) among the population from Valencia is similar to that reported in other European areas and suggest that the development of anti-Wr(a) is facilitated by the presence of a hyperactive immune system. The clinical relevance of anti-Wr(a) is limited, however.
本研究报告了西班牙巴伦西亚Wr(a)抗原和抗Wr(a)的发生率。
估计了110,000名健康献血者中Wr(a)抗原的发生率。同样，对由730名健康献血者、356名孕妇和581名来自西班牙巴伦西亚地区接受输血的患者组成的人群中抗Wr(a)的发生率进行了分析。
Wr(a)抗原的发生率为1/785。总体而言，在59个样本中发现了抗Wr(a)：20名健康献血者（1/37）、18名孕妇（1/20）和21名接受输血的患者（1/28）。健康献血者中抗Wr(a)最常见的免疫球蛋白类别是单独的免疫球蛋白M（8例）或加免疫球蛋白G（IgG；8例）；IgG1和IgG3是在孕妇（12例）和接受输血的患者（12例）中最常检测到的IgG亚类。只有51%的抗Wr(a)似乎具有临床意义。
这些数据表明，巴伦西亚人群中Wr(a)抗原和抗Wr(a)的发生率与其他欧洲地区报告的相似，并表明免疫系统活跃会促进抗Wr(a)的产生。然而，抗Wr(a)的临床相关性有限。
