Metter E Jeffrey, Schrager Mathew, Ferrucci Luigi, Talbot Laura A
National Institute on Aging, 3001 South Hanover Street, Baltimore, MD 21225, USA.
J Gerontol A Biol Sci Med Sci. 2005 Jul;60(7):840-6. doi: 10.1093/gerona/60.7.840.
Muscle power is associated with mortality independent of strength, suggesting that movement speed and coordination convey health-related information. We hypothesized that movement speed is a marker of longevity. Our participants included 1196 men who performed a tapping and/or auditory simple (respond to a sound) and disjunctive (respond to a higher pitched sound) reaction-time tasks while participating in the Baltimore Longitudinal Study of Aging. Mortality was assessed over 40 years. Tapping time was associated with mortality (relative risk [RR] = 1.34 per minute, 95% confidence interval [CI], 1.05-1.70) adjusted for age, and persisted with adjustments for arm strength and power. Simple (RR = 1.17 per 100 ms, 95% CI, 1.03-1.32) and disjunctive (RR = 1.14 per 100 ms, 95% CI, 1.03-1.27) reaction times but not their difference (RR = 1.04 per 100 ms, 95% CI, 0.92-1.19) were associated with mortality after adjustments for age, neurological/psychiatric and neck/arm pain histories. Age-associated impairments in motor control systems but not the decision to move affects longevity.
肌肉力量与死亡率相关，且独立于肌肉强度，这表明运动速度和协调性传递着与健康相关的信息。我们假设运动速度是长寿的一个标志。我们的参与者包括1196名男性，他们在参与巴尔的摩纵向衰老研究时，进行了敲击和/或听觉简单（对声音做出反应）及分离（对更高音调的声音做出反应）反应时间任务。在40年的时间里对死亡率进行了评估。在对年龄进行调整后，敲击时间与死亡率相关（相对风险[RR]=每分钟1.34，95%置信区间[CI]，1.05 - 1.70），并且在对臂力和力量进行调整后仍然显著。在对年龄、神经/精神病史和颈部/手臂疼痛史进行调整后，简单反应时间（RR =每100毫秒1.17，95% CI，1.03 - 1.32）和分离反应时间（RR =每100毫秒1.14，95% CI，1.03 - 1.27）与死亡率相关，但它们的差值（RR =每100毫秒1.04，95% CI，0.92 - 1.19）与死亡率无关。与年龄相关的运动控制系统损伤而非运动决策影响寿命。
