以杂芳基脲为二肽基肽酶IV抑制剂的吡唑烷衍生物。
Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors.
作者信息
Ahn Jin Hee, Jung Sun Ho, Kim Jin Ah, Song Seog Beom, Kwon Soon Ji, Kim Kwang Rok, Rhee Sang Dal, Park Sung-Dae, Lee Jae Mok, Kim Sung Soo, Cheon Hyae Gyeong
机构信息
Medicinal Science Division, Korea Research Institute of Chemical Technology, Taejon 305-600, Korea.
出版信息
Chem Pharm Bull (Tokyo). 2005 Aug;53(8):1048-50. doi: 10.1248/cpb.53.1048.
PMID:16079547
Abstract
In the continuation of efforts to modify the structure of our novel DP-IV inhibitors, a series of pyrazolidine derivatives with heteroaryl urea was synthesized and evaluated for their ability to inhibit dipeptidyl peptidase IV (DP-IV).
摘要
在继续努力改变我们新型二肽基肽酶-IV（DP-IV）抑制剂结构的过程中，合成了一系列带有杂芳基脲的吡唑烷衍生物，并对其抑制二肽基肽酶IV（DP-IV）的能力进行了评估。
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