Defoor Johan, Martens Kevin, Matthijs Gert, Zieliñska Dominika, Schepers Dirk, Philips Tim, Vlietinck Robert, Fagard Robert, Vanhees Luc
Cardiovascular Rehabilitation Unit, Department of Rehabilitation Sciences, K.U. Leuven, Leuven, Belgium.
Eur J Cardiovasc Prev Rehabil. 2005 Aug;12(4):415-7. doi: 10.1097/01.hjr.0000170266.30562.59.
In 927 biologically unrelated Caucasian patients with coronary artery disease it was investigated whether the NcoI restriction fragment length polymorphism of the muscle-specific creatine kinase (CKMM) gene is associated with aerobic power and with the response to physical training. Physical training significantly (P<0.001) increased peak oxygen consumption in the GG, AG and AA NcoI genotypes. Covariate-adjusted peak oxygen consumption at baseline, after training and the response to training were not different across CKMM NcoI genotypes.
在927名无血缘关系的患冠状动脉疾病的白种人患者中，研究了肌肉特异性肌酸激酶（CKMM）基因的NcoI限制性片段长度多态性是否与有氧能力以及体育锻炼反应相关。体育锻炼使GG、AG和AA NcoI基因型的峰值摄氧量显著增加（P<0.001）。在CKMM NcoI基因型中，经协变量调整后的基线峰值摄氧量、锻炼后的峰值摄氧量以及锻炼反应并无差异。
