肿瘤生物学：癌前肿瘤中的细胞衰老

Tumour biology: senescence in premalignant tumours.

作者信息

Collado Manuel, Gil Jesús, Efeyan Alejo, Guerra Carmen, Schuhmacher Alberto J, Barradas Marta, Benguría Alberto, Zaballos Angel, Flores Juana M, Barbacid Mariano, Beach David, Serrano Manuel

机构信息

Spanish National Cancer Centre (CNIO), Madrid 28029, Spain.

出版信息

Nature. 2005 Aug 4;436(7051):642. doi: 10.1038/436642a.

DOI:10.1038/436642a

PMID:16079833

Abstract

Oncogene-induced senescence is a cellular response that may be crucial for protection against cancer development, but its investigation has so far been restricted to cultured cells that have been manipulated to overexpress an oncogene. Here we analyse tumours initiated by an endogenous oncogene, ras, and show that senescent cells exist in premalignant tumours but not in malignant ones. Senescence is therefore a defining feature of premalignant tumours that could prove valuable in the diagnosis and prognosis of cancer.

摘要

癌基因诱导的衰老（OIS）是一种细胞反应，它对于预防癌症发展可能至关重要，但其研究至今仅限于经过人工操作以过度表达癌基因的培养细胞。在这里，我们分析了由内源性癌基因Ras引发的肿瘤，结果显示衰老细胞存在于癌前肿瘤中，但在恶性肿瘤中却不存在。因此，衰老现象是癌前肿瘤的一个决定性特征，这在癌症的诊断和预后方面可能具有重要价值。