Koga Jun-ichiro, Ohno Masahiko, Okamoto Kazuhiko, Nakasuga Kazuta, Ito Hiroyuki, Nagafuji Koji, Shimono Nobuyuki, Koga Hideyuki, Hayashida Akihiro, Arita Takeshi, Maruyama Toru, Kaji Yoshikazu, Harada Mine
Department of Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan.
Angiology. 2005 Jul-Aug;56(4):497-501. doi: 10.1177/000331970505600420.
Cholesterol embolization (CE) is a potentially serious complication associated with invasive arterial maneuvers, in which standard therapy has not been established. We experienced two cases of CE in patients with severe atherosclerosis whose renal function deteriorated within a few months after invasive arterial maneuvers. CE was confirmed either by renal biopsy (case 1) or skin biopsy (case 2). Oral administration of prednisolone at a daily dose of 30 mg (0.4 mg/kg) was effective to improve their renal function. Our observation suggests that corticosteroid therapy may be beneficial in some patients with CE.
胆固醇栓塞（CE）是一种与侵入性动脉操作相关的潜在严重并发症，目前尚未确立标准治疗方法。我们遇到了两例严重动脉粥样硬化患者发生CE的病例，他们在侵入性动脉操作后的几个月内肾功能恶化。通过肾活检（病例1）或皮肤活检（病例2）确诊为CE。每日口服30毫克（0.4毫克/千克）泼尼松龙可有效改善他们的肾功能。我们的观察表明，皮质类固醇治疗可能对某些CE患者有益。
