Kahn R, Buse J, Ferrannini E, Stern M
American Diabetes Association, 1701 N. Beauregard Street, Alexandria, VA 22311, USA.
Diabetologia. 2005 Sep;48(9):1684-99. doi: 10.1007/s00125-005-1876-2.
The term 'metabolic syndrome' refers to a clustering of specific cardiovascular disease (CVD) risk factors whose underlying pathophysiology is thought to be related to insulin resistance.
Since the term is widely used in research and clinical practice, we undertook an extensive review of the literature in relation to the syndrome's definition, underlying pathogenesis, association with cardiovascular disease and to the goals and impact of treatment.
While there is no question that certain CVD risk factors are prone to cluster, we found that the metabolic syndrome has been imprecisely defined, there is a lack of certainty regarding its pathogenesis, and there is considerable doubt regarding its value as a CVD risk marker. Our analysis indicates that too much critically important information is missing to warrant its designation as a 'syndrome'.
Until much-needed research is completed, clinicians should evaluate and treat all CVD risk factors without regard to whether a patient meets the criteria for diagnosis of the 'metabolic syndrome'.
“代谢综合征”一词指的是特定心血管疾病（CVD）危险因素的聚集，其潜在的病理生理学被认为与胰岛素抵抗有关。
由于该术语在研究和临床实践中被广泛使用，我们对有关该综合征的定义、潜在发病机制、与心血管疾病的关联以及治疗目标和影响的文献进行了广泛综述。
虽然某些心血管疾病危险因素容易聚集这一点毋庸置疑，但我们发现代谢综合征的定义并不精确，其发病机制尚不确定，作为心血管疾病风险标志物的价值也备受质疑。我们的分析表明，缺少太多至关重要的信息，不足以将其认定为一种“综合征”。
在急需的研究完成之前，临床医生应评估和治疗所有心血管疾病危险因素，而不必考虑患者是否符合“代谢综合征”的诊断标准。
