Department of Ambulatory Care and Community Medicine Institute of Social and Preventive Medicine, Lausanne University Hospital, Rue du Bugnon 44, Lausanne, Switzerland.
Diabet Med. 2010 Nov;27(11):1241-9. doi: 10.1111/j.1464-5491.2010.03094.x.
To investigate the relationship of alcohol consumption with the metabolic syndrome and diabetes in a population-based study with high mean alcohol consumption. Few data exist on these conditions in high-risk drinkers.
In 6172 adults aged 35-75 years, alcohol consumption was categorized as 0, 1-6, 7-13, 14-20, 21-27, 28-34 and ≥ 35 drinks/week or as non-drinkers (0), low-risk (1-13), medium-to-high-risk (14-34) and very-high-risk (≥ 35) drinkers. Alcohol consumption was objectively confirmed by biochemical tests. In multivariate analysis, we assessed the relationship of alcohol consumption with adjusted prevalence of the metabolic syndrome, diabetes and insulin resistance, determined with the homeostasis model assessment of insulin resistance (HOMA-IR).
Seventy-three per cent of participants consumed alcohol, 16% were medium-to-high-risk drinkers and 2% very-high-risk drinkers. In multivariate analysis, the prevalence of the metabolic syndrome, diabetes and mean HOMA-IR decreased with low-risk drinking and increased with high-risk drinking. Adjusted prevalence of the metabolic syndrome was 24% in non-drinkers, 19% in low-risk (P<0.001 vs. non-drinkers), 20% in medium-to-high-risk and 29% in very-high-risk drinkers (P=0.005 vs. low-risk). Adjusted prevalence of diabetes was 6.0% in non-drinkers, 3.6% in low-risk (P<0.001 vs. non-drinkers), 3.8% in medium-to-high-risk and 6.7% in very-high-risk drinkers (P=0.046 vs. low-risk). Adjusted HOMA-IR was 2.47 in non-drinkers, 2.14 in low-risk (P<0.001 vs. non-drinkers), 2.27 in medium-to-high-risk and 2.53 in very-high-risk drinkers (P=0.04 vs. low-risk). These relationships did not differ according to beverage types.
Alcohol has a U-shaped relationship with the metabolic syndrome, diabetes and HOMA-IR, without differences between beverage types.
在一项基于人群的研究中，调查饮酒与代谢综合征和糖尿病之间的关系，该研究人群的平均酒精摄入量较高。在高风险饮酒者中，关于这些情况的数据很少。
在 6172 名年龄在 35-75 岁的成年人中，将饮酒量分为 0、1-6、7-13、14-20、21-27、28-34 和≥35 份/周或不饮酒（0）、低风险（1-13）、中-高风险（14-34）和高风险（≥35）饮酒者。通过生化测试客观地确认饮酒量。在多变量分析中，我们评估了饮酒与调整后的代谢综合征、糖尿病和胰岛素抵抗（HOMA-IR）的患病率之间的关系，胰岛素抵抗的稳态模型评估（HOMA-IR）来确定。
73%的参与者饮酒，16%为中-高风险饮酒者，2%为高风险饮酒者。在多变量分析中，低风险饮酒者的代谢综合征、糖尿病和平均 HOMA-IR 患病率下降，而高风险饮酒者的患病率则升高。非饮酒者的代谢综合征患病率为 24%，低风险饮酒者为 19%（P<0.001 与非饮酒者相比），中-高风险饮酒者为 20%，高风险饮酒者为 29%（P=0.005 与低风险饮酒者相比）。非饮酒者的糖尿病患病率为 6.0%，低风险饮酒者为 3.6%（P<0.001 与非饮酒者相比），中-高风险饮酒者为 3.8%，高风险饮酒者为 6.7%（P=0.046 与低风险饮酒者相比）。非饮酒者的 HOMA-IR 为 2.47，低风险饮酒者为 2.14（P<0.001 与非饮酒者相比），中-高风险饮酒者为 2.27，高风险饮酒者为 2.53（P=0.04 与低风险饮酒者相比）。这些关系不因饮料类型而异。
酒精与代谢综合征、糖尿病和 HOMA-IR 呈 U 型关系，不同饮料类型之间没有差异。
