Boellaard Ronald, Knaapen Paul, Rijbroek Abraham, Luurtsema Gert J J, Lammertsma Adriaan A
Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands.
Mol Imaging Biol. 2005 Jul-Aug;7(4):273-85. doi: 10.1007/s11307-005-0007-2.
Parametric analysis of (15)O-water positron emission tomography (PET) studies allows determination of blood flow (BF), perfusable tissue fraction (PTF), and volume of distribution (V (d)) with high spatial resolution. In this paper the performance of basis function and linear least squares methods for generating parametric flow data were evaluated.
Monte Carlo simulations were performed using typical perfusion values for brain, tumor, and heart. Clinical evaluation was performed using seven cerebral and 10 myocardial (15)O-water PET studies. Basis function (BFM), linear least squares (LLS), and generalized linear least squares (GLLS) methods were used to calculate BF, PTF, or V(d).
Monte Carlo simulations and human studies showed that, for low BF values (<1 ml/min(-1)ml(-1), BF, PTF, and V(d) were calculated with accuracies better than 5% for all methods tested. For high BF (>2 ml/min(-1)ml(-1)), use of BFM provided more accurate V(d) compared with (G)LLS.
In general, BFM provided the most accurate estimates of BF, PTF, and V(d).
对（15）O - 水正电子发射断层扫描（PET）研究进行参数分析，能够以高空间分辨率测定血流量（BF）、可灌注组织分数（PTF）和分布容积（V（d））。本文评估了用于生成参数化血流数据的基函数法和线性最小二乘法的性能。
使用脑、肿瘤和心脏的典型灌注值进行蒙特卡罗模拟。使用7例脑部和10例心肌（15）O - 水PET研究进行临床评估。采用基函数法（BFM）、线性最小二乘法（LLS）和广义线性最小二乘法（GLLS）计算BF、PTF或V（d）。
蒙特卡罗模拟和人体研究表明，对于低BF值（<1 ml/min-1ml-1），所有测试方法计算BF、PTF和V（d）的准确度均优于5%。对于高BF（>2 ml/min-1ml-1），与（G）LLS相比，使用BFM可提供更准确的V（d）。
总体而言，BFM对BF、PTF和V（d）的估计最为准确。
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