Fahlström Markus, Appel Lieuwe, Kumlien Eva, Danfors Torsten, Engström Mathias, Wikström Johan, Antoni Gunnar, Larsson Elna-Marie, Lubberink Mark
Department of Surgical Sciences, Uppsala University, 75185 Uppsala, Sweden.
Department of Neuroscience, Uppsala University, 75185 Uppsala, Sweden.
Diagnostics (Basel). 2021 May 1;11(5):821. doi: 10.3390/diagnostics11050821.
Cerebral blood flow (CBF) measurements are of high clinical value and can be acquired non-invasively with no radiation exposure using pseudo-continuous arterial spin labeling (ASL). The aim of this study was to evaluate accordance in resting state CBF between ASL (CBF) and O-water positron emission tomography (PET) (CBF) acquired simultaneously on an integrated 3T PET/MR system. The data comprised ASL and dynamic O-water PET data with arterial blood sampling of eighteen subjects (eight patients with focal epilepsy and ten healthy controls, age 21 to 61 years). O-water PET parametric CBF images were generated using a basis function implementation of the single tissue compartment model. Cortical and subcortical regions were automatically segmented using Freesurfer. Average CBF and CBF in grey matter were 60 ± 20 and 75 ± 22 mL/100 g/min respectively, with a relatively high correlation ( = 0.78, < 0.001). Bland-Altman analysis revealed poor agreement (bias = -15 mL/100 g/min, lower and upper limits of agreements = -16 and 45 mL/100 g/min, respectively) with a negative relationship. Accounting for the negative relationship, the width of the limits of agreement could be narrowed from 61 mL/100 g/min to 35 mL/100 g/min using regression-based limits of agreements. Although a high correlation between CBF and CBF was found, the agreement in absolute CBF values was not sufficient for ASL to be used interchangeably with O-water PET.
脑血流量（CBF）测量具有很高的临床价值，并且可以使用伪连续动脉自旋标记（ASL）在无辐射暴露的情况下进行无创获取。本研究的目的是评估在集成3T PET/MR系统上同时采集的ASL（CBF）和O水正电子发射断层扫描（PET）（CBF）在静息状态下CBF的一致性。数据包括18名受试者（8名局灶性癫痫患者和10名健康对照，年龄21至61岁）的ASL和动态O水PET数据以及动脉血采样。使用单组织隔室模型的基函数实现生成O水PET参数CBF图像。使用FreeSurfer自动分割皮质和皮质下区域。灰质的平均CBF和CBF分别为60±20和75±22 mL/100 g/min，具有相对较高的相关性（= 0.78，<0.001）。Bland-Altman分析显示一致性较差（偏差=-15 mL/100 g/min，一致性下限和上限分别为-16和45 mL/100 g/min），呈负相关。考虑到负相关关系，使用基于回归的一致性界限可以将一致性界限的宽度从61 mL/100 g/min缩小到35 mL/100 g/min。尽管发现CBF和CBF之间存在高度相关性，但绝对CBF值的一致性不足以使ASL与O水PET互换使用。
