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雾化多黏菌素治疗多重耐药鲍曼不动杆菌和铜绿假单胞菌所致肺炎

Nebulized colistin in the treatment of pneumonia due to multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa.

作者信息

Kwa Andrea L H, Loh ChinSiew, Low Jenny G H, Kurup Asok, Tam Vincent H

机构信息

Division of Infectious Diseases, Department of Pharmacy, Singapore General Hospital, Singapore.

出版信息

Clin Infect Dis. 2005 Sep 1;41(5):754-7. doi: 10.1086/432583. Epub 2005 Jul 20.

DOI:10.1086/432583
PMID:16080101
Abstract

Twenty-one patients with multidrug-resistant (MDR) Acinetobacter baumannii and Pseudomonas aeruginosa pneumonia were treated with nebulized polymyxin E (colistin). Overall clinical and microbiological response rates were 57.1% and 85.7%, respectively. Nebulized colistin may be reasonably efficacious and safe for treatment of MDR pneumonia. Its role in therapy warrants further investigation in comparative studies.

摘要

21例耐多药鲍曼不动杆菌和铜绿假单胞菌肺炎患者接受了雾化多粘菌素E（黏菌素）治疗。总体临床和微生物学反应率分别为57.1%和85.7%。雾化黏菌素治疗耐多药肺炎可能相当有效且安全。其在治疗中的作用值得在比较研究中进一步探讨。

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