Costa Ana Paula Araujo, Lima Aline Maria Vasconcelos, da Silva Luiz Henrique, de Oliveira Alves Carvalho Rosângela, do Amaral Andréia Vitor Couto, Borges Naida Cristina
Department of Veterinary Medicine, School of Veterinary Medicine and Animal Science, Veterinary Hospital, Federal University of Goiás, Campus Samambaia, Caixa Postal 131, Goiânia, Goiás State, CEP 74001-970, Brazil.
Department of Veterinary Medicine, School of Veterinary Medicine and Animal Science, Federal University of Goiás, Jataí, GO, Brazil.
BMC Vet Res. 2016 Jul 22;12(1):149. doi: 10.1186/s12917-016-0778-5.
It has been proposed that sildenafil citrate can increase ocular blood flow, and that this property can be used to treat ocular disorders that involve reflex vasoconstriction. This study therefore proposes to ascertain the vasodilator effect of the drug on retrobulbar circulation in healthy rabbits. For this matter rabbits treated with sildenafil citrate or saline solution had their intraocular pressure (IOP), mean arterial pressure (MAP), ocular perfusion pressure (OPP) and color Doppler imaging of the external ophthalmic artery measured prior to treatment and on days one (moment M1), seven (when M2), fourteen (moment M3), twenty-one (moment M4), and thirty (moment M5) of treatment.
The MAP and OPP values of treated group were lower than those of control group at all times, and the mean values differed statistically at moments M1 (S = 71.52 mmHg, C = 84.76 mmHg, p = 0.0356) and M5 (S = 71.38 mmHg, C = 85.52 mmHg, p = 0.0252). The IOP and color Doppler values of the external ophthalmic artery did not differ between tested groups.
The dose of 10 mg of sildenafil citrate administered to healthy rabbits causes systemic vasodilation and consequently lower values of MAP and OPP. However, it does not induce changes in IOP and retrobulbar hemodynamics identifiable by color Doppler assessment of the external ophthalmic artery.
有人提出，枸橼酸西地那非可增加眼部血流量，且这一特性可用于治疗涉及反射性血管收缩的眼部疾病。因此，本研究旨在确定该药物对健康兔球后循环的血管舒张作用。为此，在用枸橼酸西地那非或生理盐水治疗的兔中，在治疗前以及治疗的第1天（时刻M1）、第7天（时刻M2）、第14天（时刻M3）、第21天（时刻M4）和第30天（时刻M5）测量其眼压（IOP）、平均动脉压（MAP）、眼灌注压（OPP）以及眼外动脉的彩色多普勒成像。
治疗组的MAP和OPP值在所有时间均低于对照组，且在时刻M1（S = 71.52 mmHg，C = 84.76 mmHg，p = 0.0356）和M5（S = 71.38 mmHg，C = 85.52 mmHg，p = 0.0252）时平均值有统计学差异。测试组之间眼外动脉的IOP和彩色多普勒值没有差异。
给予健康兔10 mg枸橼酸西地那非剂量会引起全身血管舒张，从而导致MAP和OPP值降低。然而，通过眼外动脉的彩色多普勒评估，它不会引起IOP和球后血流动力学的变化。
