Mieno Shigetoshi, Horimoto Hitoshi, Asada Kunio, Sasaki Shinjiro
Int J Cardiol. 2005 Aug 18;103(2):214-6. doi: 10.1016/j.ijcard.2004.08.066.
Primary chordal rupture is a leading cause of severe mitral regurgitation requiring surgery. It has previously been documented that there is a high probability of the occurrence of primary chordal rupture in patients with histological evidence of myxysomatous changes in the mitral valve. The precise etiology of primary chordal rupture and/or myxysomatous changes remains obscure and the relative contribution of genetic factors is debated. We report a pair of middle-aged identical twins requiring surgery for mitral regurgitation due to primary chordal rupture, and discuss the etiology of primary chordal rupture and/or myxysomatous changes.
原发性腱索断裂是导致严重二尖瓣反流需行手术治疗的主要原因。此前已有文献记载，二尖瓣存在黏液样变性组织学证据的患者发生原发性腱索断裂的可能性很高。原发性腱索断裂和/或黏液样变性的确切病因仍不明确，遗传因素的相对作用也存在争议。我们报告了一对因原发性腱索断裂导致二尖瓣反流而需要手术治疗的中年同卵双胞胎，并讨论原发性腱索断裂和/或黏液样变性的病因。
