Nishiyama T, Hirasaki A, Odaka Y, Konishi H, Tsubaki N, Seto K
Department of Anesthesiology, Kagawa Prefectural Central Hospital, Takamatsu.
Masui. 1992 May;41(5):733-9.
The studies were performed to find out whether increased serum levels of polymorphonuclear leukocyte elastase (PMNE) depend on increase of segmented neutrophils or increase of PMNE release from a segmented neutrophil on 17 patients for various elective surgeries. Serum levels of PMNE, leukocyte count and leukogram were determined before incision (preoperation), as well as on the 1st, 3rd and 5th day after operation. Serum levels of PMNE, segmented cell count, stab cell count, stab cell-segmented cell ratio increased most on the 1st postoperative day and decreased thereafter. Leukocyte count showed no significant changes. Serum levels of PMNE correlated well with PMNE released from a segmented neutrophil, but not with leukocyte count or segmented cell count. It was concluded that increased serum levels of PMNE by surgical stress depend on the increased PMNE release from a segmented neutrophil but not on the increased segmented cell count.
对17例接受各种择期手术的患者进行了研究，以确定血清多形核白细胞弹性蛋白酶（PMNE）水平升高是否取决于分叶中性粒细胞数量的增加或分叶中性粒细胞释放PMNE的增加。在切口前（术前）以及术后第1、3和5天测定血清PMNE水平、白细胞计数和白细胞分类计数。血清PMNE水平、分叶细胞计数、杆状细胞计数、杆状细胞-分叶细胞比率在术后第1天增加最多，此后下降。白细胞计数无显著变化。血清PMNE水平与分叶中性粒细胞释放的PMNE密切相关，但与白细胞计数或分叶细胞计数无关。得出的结论是，手术应激导致的血清PMNE水平升高取决于分叶中性粒细胞释放PMNE的增加，而不是分叶细胞数量的增加。
