Hara H, Ban Y
3rd Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan.
Endocr J. 1993 Dec;40(6):711-4. doi: 10.1507/endocrj.40.711.
We studied plasma polymorphonuclear elastase (PMNE) levels before and during methimazole treatment in patients with hyperthyroidism. Plasma PMNE levels in patients with hyperthyroidism were significantly higher than those of normal subjects and patients with thyroid adenoma. Plasma PMNE levels in patients with Graves' disease were significantly reduced when their thyroid functions after methimazole treatment were normal, compared with the levels of the patients before treatment. In patients with hyperthyroidism there was a significant positive correlation between plasma PMNE and serum FT3, but no correlation between plasma PMNE and serum TRAb. The results suggested that PMNE was secreted from blood neutrophil in hyperthyroid state patients with Graves' disease and that it was beneficial for helping determining peripheral thyroid function.
我们研究了甲亢患者在服用甲巯咪唑治疗前及治疗期间的血浆多形核弹性蛋白酶（PMNE）水平。甲亢患者的血浆PMNE水平显著高于正常受试者和甲状腺腺瘤患者。与治疗前相比，格雷夫斯病患者在甲巯咪唑治疗后甲状腺功能正常时，其血浆PMNE水平显著降低。甲亢患者血浆PMNE与血清FT3之间存在显著正相关，但血浆PMNE与血清TRAb之间无相关性。结果表明，PMNE由格雷夫斯病甲亢状态患者的血液中性粒细胞分泌，且有助于判断外周甲状腺功能。
