Kitaguchi K, Nakajima T, Takaki O, Uchida O, Hayashi Y, Ohnishi Y, Shibata H, Kuro M
Department of Anesthesiology, National Cardiovascular Center, Osaka.
Masui. 1992 May;41(5):766-71.
We investigated the effect of prostaglandin E1 (PGE1)--induced hypotension during sevoflurane anesthesia on the cerebral blood flow (CBF), autoregulation and internal jugular venous O2 tension (PjO2) in 8 patients undergoing neurosurgery. Although the mean arterial pressure decreased from 95.3 +/- 3.8 mmHg (mean +/- SD) to 63.6 +/- 8.0 mmHg by continuous intravenous infusion of PGE1, CBF did not change significantly (97.2 +/- 10.6% of control value). During hypotensive anesthesia, autoregulation was well maintained in all patients, and the values of PjO2 did not suggest brain hypoxia at all. The results indicate that hypotensive anesthesia induced by PGE1 and sevoflurane is a safe and a reliable method for neuroanesthesia.
我们研究了8例接受神经外科手术患者在七氟烷麻醉期间，前列腺素E1（PGE1）诱导的低血压对脑血流量（CBF）、自动调节功能及颈内静脉血氧分压（PjO2）的影响。尽管通过持续静脉输注PGE1使平均动脉压从95.3±3.8 mmHg（平均值±标准差）降至63.6±8.0 mmHg，但CBF无显著变化（为对照值的97.2±10.6%）。在低血压麻醉期间，所有患者的自动调节功能均维持良好，且PjO2值完全未提示脑缺氧。结果表明，PGE1和七氟烷诱导的低血压麻醉是一种安全可靠的神经麻醉方法。
