Hasegawa J, Mitsuhata H, Matsumoto S, Komatsu H, Mizunuma T
Department of Anaesthesiology, Hiraka General Hospital, Yokote.
Masui. 1992 May;41(5):772-8.
The effects of induced hypotension with sevoflurane and PGE1 (Group S) on liver functions during neurosurgery that can avoid direct invasion of the liver were retrospectively studied in 35 cases, in comparison with 8 cases of isoflurane and PGE1 induced hypotension (Group I). GOT, GPT and gamma-GTP increased slightly in both groups 1 day and 1 week after operation, but they returned to preoperative levels 1 month later. ChE decreased in both groups, and the decrease was greater in group S. Three cases in Group S (8.6%) and one case in Group I (12.5%) showed GOT or GPT over 100 and there was no significant difference in the two groups. Hypotensive anaesthesia induced with sevoflurane and PGE1 in neurosurgery, as that induced with isoflurane and PGE1, has little effect on postoperative liver functions.
回顾性研究了35例在神经外科手术中使用七氟醚和前列腺素E1诱导低血压（S组）对肝功能的影响，该手术可避免直接侵犯肝脏，并与8例使用异氟醚和前列腺素E1诱导低血压的病例（I组）进行比较。术后1天和1周时，两组的谷草转氨酶（GOT）、谷丙转氨酶（GPT）和γ-谷氨酰转肽酶（γ-GTP）均略有升高，但1个月后恢复至术前水平。两组的胆碱酯酶（ChE）均下降，且S组下降幅度更大。S组3例（8.6%）和I组1例（12.5%）的GOT或GPT超过100，两组间无显著差异。在神经外科手术中，七氟醚和前列腺素E1诱导的低血压麻醉与异氟醚和前列腺素E1诱导的低血压麻醉一样，对术后肝功能影响较小。
