Nakagawa Naoko, Kubota Ritsuko, Okuno Yoshinobu
Department of Microbiology, Kobe Institute of Health, 4-6, Minatojima-nakamachi, Chuo-ku, Kobe, 650-0046 Japan.
J Clin Microbiol. 2005 Aug;43(8):4212-4. doi: 10.1128/JCM.43.8.4212-4214.2005.
For almost 20 years, the neutralizing-epitope site specific for influenza B virus Victoria group isolates was conserved at the "tip" of the hemagglutinin molecule; however, it was not detected in half of the isolates from the 2002-2003 epidemic in Japan. Amino acid substitutions (D164E or N165K) were observed at the "tip", and the epitope was altered. The viral antigenicities were affected, and human antibodies did not substantially inhibit the hemagglutination in the hemagglutination inhibition tests. It is suspected that such variants will be important in future epidemics.
近20年来，针对乙型流感病毒维多利亚系毒株的中和表位在血凝素分子的“顶端”一直保持保守；然而，在日本2002 - 2003年流行期间分离出的毒株中，有一半未检测到该表位。在“顶端”观察到氨基酸替换（D164E或N165K），且表位发生了改变。病毒抗原性受到影响，在血凝抑制试验中，人源抗体对血凝的抑制作用大幅下降。据推测，此类变异株在未来的流行中将具有重要意义。
