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在一名人类免疫缺陷病毒阳性患者中，对作为慢性舌溃疡病原体的纤维微杆菌进行分子检测。

Molecular detection of Cellulosimicrobium cellulans as the etiological agent of a chronic tongue ulcer in a human immunodeficiency virus-positive patient.

作者信息

Heym Beate, Gehanno Pierre, Friocourt Véronique, Bougnoux Marie-Elisabeth, Le Moal Michèle, Husson Corinne, Leibowitch Jacques, Nicolas-Chanoine Marie-Hélène

机构信息

Microbiology Department, Hôpital Ambroise Paré, Boulogne, France.

出版信息

J Clin Microbiol. 2005 Aug;43(8):4269-71. doi: 10.1128/JCM.43.8.4269-4271.2005.

DOI:10.1128/JCM.43.8.4269-4271.2005
PMID:16081997
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1234009/
Abstract

Ulcerations appeared on the tongue of a 48-year-old human immunodeficiency virus-positive man. Histological findings of the biopsy specimen and the fact that the patient had resided in Louisiana led us to suspect "American histoplasmosis". A new ulcer appeared while the patient was being treated with itraconazole, and the gene for 16S rRNA of Cellulosimicrobium cellulans was amplified. The lesions healed during treatment with oral penicillin and azithromycin.

摘要

一名48岁的人类免疫缺陷病毒阳性男子的舌头上出现了溃疡。活检标本的组织学检查结果以及该患者曾居住在路易斯安那州这一事实，使我们怀疑是“美洲组织胞浆菌病”。在患者接受伊曲康唑治疗期间出现了新的溃疡，并且扩增出了纤维微杆菌16S rRNA的基因。在口服青霉素和阿奇霉素治疗期间，病变愈合。