Leinot M, Basiez M, Talvard J, Labrid C
C R Seances Soc Biol Fil. 1979;173(4):773-80.
The effects of bepridil, nifedipine, verapamil, lignocaïne and amiodarone on the atrial effective refractory period were investigated in the guinea-pig. The observed results permitted elucidation of a remarkable activity by both nifedipine and verapamil, and by bepridil and lignocaïne. In contrast, in the experimental conditions, no activity was detected with amiodarone up to concentrations of 10(-4) M. The efficacity rating of the test compounds is not reflected by their anti-arrhythmic efficacity as demonstrated in vivo in the animal, nor by their therapeutic anti-arrhythmic efficacity as reported in the clinical literature. However, this efficacity rating may be related to the interaction of the compounds with the transmembrane sodium or calcium movements.
在豚鼠身上研究了苄普地尔、硝苯地平、维拉帕米、利多卡因和胺碘酮对心房有效不应期的影响。观察结果表明硝苯地平和维拉帕米、苄普地尔和利多卡因均具有显著活性。相比之下，在实验条件下，浓度高达10(-4)M时，未检测到胺碘酮有活性。受试化合物的效力评级既不能通过其在动物体内的抗心律失常效力体现，也不能通过临床文献报道的治疗性抗心律失常效力体现。然而，这种效力评级可能与化合物与跨膜钠或钙运动的相互作用有关。
