Anderlová K, Kremen J, Dolezalová R, Housová J, Haluzíková D, Kunesová M, Haluzík M
Third Department of Medicine and 1 Faculty of Medicine, Charles University, U Nemocnice 1, 128 00 Prague 2. Czech Republic.
Physiol Res. 2006;55(3):277-283. doi: 10.33549/physiolres.930779. Epub 2005 Aug 5.
The aim of our study was to determine whether adipocyte-derived hormones leptin, adiponectin and resistin contribute to the improvement of insulin sensitivity after very-low calorie diet (VLCD). Therefore, serum levels of these hormones were measured in fourteen obese females before and after three weeks VLCD and in seventeen age- and sex-matched healthy controls. Body mass index, HOMA index, serum insulin and leptin levels in obese women before VLCD were significantly higher than in control group (BMI 48.01+/-2.02 vs. 21.38+/-0.42 kg/m(2), HOMA 10.72+/-2.03 vs. 4.69+/-0.42, insulin 38.63+/-5.10 vs. 18.76+/-1.90 microIU/ml, leptin 77.87+/-8.98 vs. 8.82+/-1.52 ng/ml). In contrast, serum adiponectin and soluble leptin receptors levels were significantly lower in obese women before VLCD than in the control group. No differences were found in serum glucose and resistin levels between the obese group before VLCD and the control group. VLCD significantly decreased BMI, HOMA index, serum glucose, insulin and leptin levels and increased soluble leptin receptor levels. The changes in serum adiponectin and resistin levels in obese women after VLCD did not reach statistical significance. We conclude that leptin and soluble leptin receptor levels were affected by VLCD while adiponectin and resistin concentrations were not. Therefore, other mechanisms rather than changes in the endocrine function of the adipose tissue are probably involved in the VLCD-induced improvement of insulin sensitivity.
我们研究的目的是确定脂肪细胞衍生的激素瘦素、脂联素和抵抗素是否有助于极低热量饮食（VLCD）后胰岛素敏感性的改善。因此，在14名肥胖女性进行为期三周的VLCD前后以及17名年龄和性别匹配的健康对照者中测量了这些激素的血清水平。VLCD前肥胖女性的体重指数、HOMA指数、血清胰岛素和瘦素水平显著高于对照组（体重指数48.01±2.02 vs. 21.38±0.42 kg/m²，HOMA 10.72±2.03 vs. 4.69±0.42，胰岛素38.63±5.10 vs. 18.76±1.90 μIU/ml，瘦素77.87±8.98 vs. 8.82±1.52 ng/ml）。相反，VLCD前肥胖女性的血清脂联素和可溶性瘦素受体水平显著低于对照组。VLCD前肥胖组与对照组之间的血清葡萄糖和抵抗素水平未发现差异。VLCD显著降低了体重指数、HOMA指数、血清葡萄糖、胰岛素和瘦素水平，并提高了可溶性瘦素受体水平。VLCD后肥胖女性血清脂联素和抵抗素水平的变化未达到统计学意义。我们得出结论，瘦素和可溶性瘦素受体水平受VLCD影响，而脂联素和抵抗素浓度不受影响。因此，VLCD诱导的胰岛素敏感性改善可能涉及脂肪组织内分泌功能变化以外的其他机制。
