Faculty of Health Sciences, San Antonio Catholic University of Murcia (UCAM), 30107, Murcia, Spain.
Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain.
Eur J Nutr. 2022 Mar;61(2):825-841. doi: 10.1007/s00394-021-02678-x. Epub 2021 Sep 30.
Polyphenols have shown capacity to improve appetite sensation, leading to enhanced control of body weight. However, despite being related with hunger-related hormones, metabolic and mechanism are not well known.
The effectiveness of a nutraceutical composed of extract to Lippia citriodora and Hibiscus sabdarrifa (Lc-Hs) for controlling satiety and hunger was analyzed in a cross-over, placebo-controlled (Pla) clinical intervention. The study was divided in two 60-day periods separated by 30-day length wash-out period. At the end of each period, overweight and obese subjects (n = 33; age = 33.76 ± 12.23; BMI = 28.20 kg/m ± 2.47; fat mass 30.65 ± 8.39%; both sexes were proposed to eat an ad-libitum meal. Meanwhile, appetite sensation was determined by visual analog scales at different times. Moreover, blood extraction was performed to determine biochemical parameters (lipid and glucidic profile and safety parameters) and to evaluate hunger-related hormones (insulin, leptin, ghrelin, adiponectin, GLP-1 and peptide YY).
A decrease in appetite sensation was observed in Lc-Hs treatment, showing higher satiety quotient (Pla = 3.36 ± 2.33%mm/kcal; Lc-Hs = 5.53 ± 2.91%mm/kcal; p < 0.0001). Area under the curve was higher in Pla compared to Lc-Hs during the test, from baseline to minute 240 (240 (Pla 9136.65 ± 2261.46% x min; Lc-Hs 8279.73 ± 2745.71% x min; p < 0.014). Energy consumption was lower for subjects treated with Lc-Hs (774.44 ± 247.77 kcal) compared to those treated with Pla (849.52 ± 246.54 kcal) (p < 0.004). Leptin values varied from baseline (Pla 12.36 ± 1.98 ng/mL; Lc-Hs 13.13 ± 1.99 ng/mL) to the end of the study (Pla 12.60 ± 2.02 ng/mL; Lc-Hs 12.06 ± 2.05 ng/mL; p < 0.047). GLP-1 values varied (p < 0.001) in Lc-Hs treatment from baseline (4.34 ± 0.49 ng/mL) to the end of the study (3.23 ± 0.52 ng/mL).
The supplementation with the Lc-Hs extract decreases appetite sensation in overweight and obese population, reducing calorie intake after an ad-libitum meal. Due to variation on hunger-related hormones and the relationship between satiety feeling, it would be interesting to develop future research focused on the variation of the hormones themselves.
多酚已被证明具有改善食欲感知的能力，从而更好地控制体重。然而，尽管与饥饿相关的激素有关，但代谢和机制尚不清楚。
通过交叉、安慰剂对照（Pla）临床干预分析了由 Lippia citriodora 和 Hibiscus sabdarrifa（Lc-Hs）提取物组成的营养保健品控制饱腹感和饥饿感的效果。该研究分为两个 60 天的周期，每个周期之间有 30 天的洗脱期。在每个周期结束时，超重和肥胖受试者（n=33；年龄=33.76±12.23；BMI=28.20kg/m2±2.47；脂肪量 30.65±8.39%；建议所有性别均随意进食。同时，通过视觉模拟量表在不同时间确定食欲感知。此外，进行血液提取以确定生化参数（脂质和糖脂谱和安全参数）和评估与饥饿相关的激素（胰岛素、瘦素、胃饥饿素、脂联素、GLP-1 和肽 YY）。
在 Lc-Hs 治疗中观察到食欲感知下降，显示出更高的饱腹感指数（Pla=3.36±2.33%mm/kcal；Lc-Hs=5.53±2.91%mm/kcal；p<0.0001）。与 Pla 相比，Lc-Hs 组在测试过程中从基线到第 240 分钟（240（Pla 9136.65±2261.46%xmin；Lc-Hs 8279.73±2745.71%xmin；p<0.014）的曲线下面积更高。与 Pla 治疗相比，接受 Lc-Hs 治疗的受试者的能量消耗更低（774.44±247.77kcal）（849.52±246.54kcal）（p<0.004）。瘦素值从基线（Pla 12.36±1.98ng/mL；Lc-Hs 13.13±1.99ng/mL）到研究结束时（Pla 12.60±2.02ng/mL；Lc-Hs 12.06±2.05ng/mL；p<0.047）发生变化。GLP-1 值在 Lc-Hs 治疗中发生变化（p<0.001），从基线（4.34±0.49ng/mL）到研究结束（3.23±0.52ng/mL）。
Lc-Hs 提取物的补充可降低超重和肥胖人群的食欲感知，减少随意餐后的热量摄入。由于与饥饿相关的激素发生变化以及饱腹感与食欲的关系，因此开展针对激素本身变化的未来研究将很有趣。
