Stern David F
Department of Pathology, Yale University School of Medicine, PO Box 208023, New Haven, CT 06520-8023, USA.
Expert Opin Ther Targets. 2005 Aug;9(4):851-60. doi: 10.1517/14728222.9.4.851.
Reversible protein phosphorylation is one of the most important forms of cellular regulation. For this reason, phosphoproteomic analysis of protein phosphorylation in cells is a powerful tool for evaluating the functional status of cells. The importance of protein kinase-regulated signal transduction pathways in human cancer has led to the development of drugs that inhibit protein kinases at the apex or intermediary levels of these pathways. Phosphoproteomic analysis of these signalling pathways will provide important insights into the operation and connectivity of these pathways that will facilitate the identification of the best targets for cancer therapies. Moreover, phosphoproteomic analysis of individual tumours will help match targeted cancer drugs to the appropriate patients.
可逆性蛋白质磷酸化是细胞调节的最重要形式之一。因此，对细胞中蛋白质磷酸化进行磷酸化蛋白质组分析是评估细胞功能状态的有力工具。蛋白激酶调节的信号转导通路在人类癌症中的重要性促使人们开发出在这些通路的顶端或中间水平抑制蛋白激酶的药物。对这些信号通路进行磷酸化蛋白质组分析将为这些通路的运作和连接提供重要见解，这将有助于确定癌症治疗的最佳靶点。此外，对单个肿瘤进行磷酸化蛋白质组分析将有助于为合适的患者匹配靶向抗癌药物。
