Kasamon Yvette L, Ambinder Richard F
Division of Hematologic Malignancies, Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Bunting-Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA.
Hematol Oncol Clin North Am. 2005 Aug;19(4):665-87, vi-vii. doi: 10.1016/j.hoc.2005.05.004.
Primary central nervous system lymphoma (PCNSL) can develop in the setting of profound immunosuppression, including late-stage infection with HIV. The management of such patients has yet to be defined optimally and differs substantially from that of immunocompetent patients who have PCNSL. The clinical features, diagnosis, and management of AIDS-related PCNSL are reviewed. The authors focus on commonly encountered diagnostic and therapeutic dilemmas and explore some promises and pitfalls of Epstein-Barr virus-directed therapies.
原发性中枢神经系统淋巴瘤（PCNSL）可在深度免疫抑制的情况下发生，包括晚期HIV感染。此类患者的管理尚未得到最佳定义，且与患有PCNSL的免疫功能正常患者的管理有很大不同。本文综述了艾滋病相关PCNSL的临床特征、诊断和管理。作者重点关注常见的诊断和治疗难题，并探讨了爱泼斯坦-巴尔病毒定向疗法的一些前景和陷阱。
