是时候给患有钙化性主动脉瓣狭窄的患者开他汀类药物了吗？

Is it time to prescribe statins to patients with calcified aortic stenosis?

作者信息

Rashidi Arash, Adler Dale S, Casscells Ward, Madjid Mohammad

机构信息

Fairview Hospital, Cleveland Clinic Health System, Cleveland, Ohio 44111, USA.

出版信息

Am Heart J. 2005 Jul;150(1):41-5. doi: 10.1016/j.ahj.2005.01.021.

DOI:10.1016/j.ahj.2005.01.021

PMID:16084149

Abstract

Aortic stenosis (AS) is a common disease especially in the older population. It is associated with high mortality and morbidity. Recent data suggest that coronary artery disease and AS share common risk factors. Retrospective studies suggest that statins might slow the progression of AS but there are no randomized clinical trial data available. It would seem that statins can be considered for medical treatment of AS; however, this needs to be investigated in future randomized clinical trials.

摘要

主动脉瓣狭窄（AS）是一种常见疾病，尤其在老年人群中。它与高死亡率和高发病率相关。近期数据表明，冠状动脉疾病和AS具有共同的风险因素。回顾性研究提示他汀类药物可能会减缓AS的进展，但尚无随机临床试验数据。似乎可以考虑将他汀类药物用于AS的药物治疗；然而，这需要在未来的随机临床试验中进行研究。