Kozaki Koichi
Department of Geriatric Medicine, Kyorin University School of Medicine.
Clin Calcium. 2006 Jan;16(1):31-6.
Vascular calcification, such as coronary and aortic calcification, is a significant feature of vascular pathology, since this lesion is associated with cardiovascular disease. Statins are potent serum cholesterol-reducing drugs, which decrease the risk of cardiovascular diseases. Besides reducing serum cholesterol levels, statins are shown to decrease the rate of coronary artery calcification by unidentified mechanism. Though previous observational studies have shown that statins decrease the rate of calcific aortic valve stenosis, recent prospective study have revealed that statins are not effective against the progression of calcific aortic stenosis. We need to establish the role of statins in the prevention of aortic valve stenosis with long-term, large-scale, randomized controlled study.
血管钙化，如冠状动脉和主动脉钙化，是血管病理学的一个重要特征，因为这种病变与心血管疾病相关。他汀类药物是强效的降低血清胆固醇的药物，可降低心血管疾病的风险。除了降低血清胆固醇水平外，他汀类药物还被证明可通过不明机制降低冠状动脉钙化率。尽管先前的观察性研究表明他汀类药物可降低钙化性主动脉瓣狭窄的发生率，但最近的前瞻性研究显示，他汀类药物对钙化性主动脉瓣狭窄的进展无效。我们需要通过长期、大规模、随机对照研究来确定他汀类药物在预防主动脉瓣狭窄中的作用。
