Wood R I, Swann J M
Department of Cell and Neurobiology, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, USA.
Neuroscience. 2005;135(1):155-79. doi: 10.1016/j.neuroscience.2005.05.029.
The bed nucleus of the stria terminalis is a key part of a ring of cells extending between the centromedial amygdala and bed nucleus of the stria terminalis referred to as the extended amygdala. The present study describes the architecture of the bed nucleus of the stria terminalis and the connections of subnuclei in posterior bed nucleus of the stria terminalis. The hamster bed nucleus of the stria terminalis is readily allotted to anterior and posterior divisions separated by the fibers of the body of the anterior commissure. The anterior division has four subnuclei: anteromedial, anterointermediate, anterolateral, and anteroventral. Within the posterior division, there are three distinct regions: posteromedial, posterointermediate, and posterolateral. In hamsters, the posterior bed nucleus of the stria terminalis contributes to male sexual behavior, particularly chemoinvestigation. Moreover, the posterior bed nucleus of the stria terminalis is part of a neural circuit essential for mating, including the medial amygdaloid nucleus and medial preoptic area. The connections of bed nucleus of the stria terminalis, posteromedial part, bed nucleus of the stria terminalis, posterointermediate part and bed nucleus of the stria terminalis, posterolateral part were visualized by co-injection of anterograde (Phaseolus vulgaris leucoagglutinin) and retrograde (cholera toxin B) tract tracers. The bed nucleus of the stria terminalis, posterointermediate part and bed nucleus of the stria terminalis, posteromedial part have dense bidirectional connections with medial amygdaloid nucleus and cortical amygdala via the stria terminalis and ventral amygdalofugal pathway. These subnuclei also maintain bidirectional connections with steroid-concentrating areas including lateral septum, medial preoptic area, hypothalamus, and periaqueductal gray. The bed nucleus of the stria terminalis, posterointermediate part and bed nucleus of the stria terminalis, posteromedial part receive projections from the subiculum and send projections to deep mesencephalic nuclei. By contrast, the bed nucleus of the stria terminalis, posterolateral part is connected with the central amygdala, lateral hypothalamus, subthalamic nucleus, nucleus accumbens, substantia innominata, substantia nigra and thalamus. Thus, the bed nucleus of the stria terminalis, posterointermediate part and bed nucleus of the stria terminalis, posteromedial part have similar connections with areas involved in social behaviors. The bed nucleus of the stria terminalis, posterolateral part maintains connections with areas involved in motivational circuits. This supports the concept of distinct circuits within the extended amygdala which differentially link the centromedial amygdala and bed nucleus of the stria terminalis.
终纹床核是一个细胞环的关键部分，该细胞环在中央内侧杏仁核和终纹床核之间延伸，被称为扩展杏仁核。本研究描述了终纹床核的结构以及终纹床核后部亚核的连接。仓鼠的终纹床核很容易分为由前连合纤维分隔的前部和后部。前部有四个亚核：前内侧、前中间、前外侧和前腹侧。在后部内，有三个不同的区域：后内侧、后中间和后外侧。在仓鼠中，终纹床核后部参与雄性性行为，尤其是化学探究行为。此外，终纹床核后部是交配所必需的神经回路的一部分，包括内侧杏仁核和内侧视前区。通过同时注射顺行（菜豆白细胞凝集素）和逆行（霍乱毒素B）示踪剂，观察到终纹床核后内侧部、终纹床核后中间部和终纹床核后外侧部的连接。终纹床核后中间部和终纹床核后内侧部通过终纹和腹侧杏仁体传出通路与内侧杏仁核和皮质杏仁核有密集的双向连接。这些亚核还与包括外侧隔、内侧视前区、下丘脑和导水管周围灰质在内的类固醇浓缩区保持双向连接。终纹床核后中间部和终纹床核后内侧部接受来自海马下脚的投射并向中脑深部核团发出投射。相比之下，终纹床核后外侧部与中央杏仁核、外侧下丘脑、底丘脑核、伏隔核、无名质、黑质和丘脑相连。因此，终纹床核后中间部和终纹床核后内侧部与参与社会行为的区域有相似的连接。终纹床核后外侧部与参与动机回路的区域保持连接。这支持了扩展杏仁核内不同回路的概念，这些回路以不同方式连接中央内侧杏仁核和终纹床核。
