Swanson L W
J Comp Neurol. 1976 May 15;167(2):227-56. doi: 10.1002/cne.901670207.
The normal morphology of the rat preoptic region has been briefly described on the basis of Nissl- and silver-stained preparations and its efferent connections have been studied autoradiographically in over 50 rat brains with single small injections of 3H-proline, or various mixtures of 3H-proline, 3H-leucine, and 3H-lysine. Injections in the anteroventral part of the lateral preoptic area labeled fibers projecting through, and perhaps to, the anterior and lateral hypothalamic areas and ending in the supramammillary region, and ventral fiber lamina of the mammillary complex; other labeled fibers ended in the periventricular hypothalamic gray and the internal lamina of the median eminence. The posteromedial lateral preoptic area projects to the same regions, as well as to the medial septal-diagonal band complex, and to the lateral habenula through the stria medullaris. Injections of the posterolateral lateral preoptic area labeled each of the above fiber systems as well as fibers to the main olfactory bulb, anterior olfactory nucleus and taenia tecta. Other fibers coursed over the genu of the corpus callosum, through the stria terminalis and ansa peduncularis to the medial, cortical and basal amygdaloid nuclei and the anterior amygdaloid area, and through the medial forebrain bundle to the substantia nigra. The transition region between the lateral preoptic and lateral hypothalamic areas at the level of the supraoptic nucleus has widespread connections as a whole (a) with the medial septal-diagonal band complex, lateral septum and bed nucleus of the stria terminalis, (b) through or to most of the hypothalamus, the substantia nigra, central tegmental field, central gray, superior central nucleus, and the locus coeruleus, (c) through the stria medullaris to the lateral habenula (bilaterally), parataenial, paraventricular, and mediodorsal nuclei of the thalamus, (d) through the stria terminalis and ansa peduncularis to the central, medial and cortical nuclei of the amygdala, and (e) to the main olfactory bulb, anterior olfactory nucleus, cingulate bundle, olfactory tubercle, medial septal-diagonal band complex and the lateral septum.
基于尼氏染色和银染色标本，已简要描述了大鼠视前区的正常形态，并通过对50多只大鼠脑进行单小剂量3H-脯氨酸或3H-脯氨酸、3H-亮氨酸和3H-赖氨酸的各种混合物注射，以放射自显影法研究了其传出连接。在视前外侧区腹前部的注射标记了穿过并可能投射到下丘脑前区和外侧区并终止于乳头体上区以及乳头复合体腹侧纤维层的纤维；其他标记纤维终止于室周下丘脑灰质和正中隆起的内板。视前外侧区后内侧部投射到相同区域，以及内侧隔-斜角带复合体，并通过髓纹投射到外侧缰核。视前外侧区后外侧部的注射标记了上述每个纤维系统以及投射到主嗅球、前嗅核和终纹床核的纤维。其他纤维越过胼胝体膝部，通过终纹和脚间袢到达杏仁核内侧核群、皮质核群和基底核群以及杏仁前区，并通过内侧前脑束到达黑质。视上核水平的视前外侧区和下丘脑外侧区之间的过渡区域总体上具有广泛的连接：（a）与内侧隔-斜角带复合体、外侧隔和终纹床核相连；（b）穿过或到达大部分下丘脑、黑质、中央被盖区、中央灰质、上中央核和蓝斑；（c）通过髓纹到达外侧缰核（双侧）、丘脑旁位核、室旁核和背内侧核；（d）通过终纹和脚间袢到达杏仁核中央核、内侧核和皮质核；（e）到达主嗅球、前嗅核、扣带束、嗅结节、内侧隔-斜角带复合体和外侧隔。
