Brown Lee K, Dedrick David L, Doggett John W, Guido Peter S
The Program in Sleep Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM 87102, USA.
Sleep Med. 2005 Sep;6(5):443-50. doi: 10.1016/j.sleep.2005.03.005.
Restless legs syndrome (RLS) is a movement disorder that frequently results in significant complaints of insomnia. Based on published case reports, it is commonly believed that RLS can be caused or exacerbated by antidepressant agents, thus complicating the treatment of depressed patients who are already prone to sleep disturbances. However, there are no systematic studies demonstrating an association between the clinical diagnosis of RLS and the use of antidepressant medication.
Retrospective chart review of 200 consecutive patients presenting for evaluation of sleep initiation insomnia at an accredited freestanding sleep disorders center that is part of an integrated health care system.
Mean age (+/-SD) of patients was 51.1+/-14.8 years; 60% were women. Fifty-six percent carried a diagnosis of depression, 38% were being treated with antidepressant medication at presentation and 45% met clinical diagnostic criteria for RLS. There were no statistical associations, either by chi(2) analysis or odds ratios, between RLS and antidepressant use or use of any specific class of antidepressant. Positive associations with RLS were found for patients receiving treatment for hypothyroidism and those taking estrogens; a significant negative association was found for patients receiving beta adrenergic antagonists.
Although there are anecdotal reports of antidepressant use causing or exacerbating RLS, systematic study of this issue fails to corroborate an association.
不宁腿综合征（RLS）是一种运动障碍性疾病，常导致严重的失眠主诉。根据已发表的病例报告，人们普遍认为抗抑郁药可引发或加重RLS，这使得本就容易出现睡眠障碍的抑郁症患者的治疗变得更加复杂。然而，尚无系统性研究证实RLS的临床诊断与抗抑郁药使用之间存在关联。
对一家隶属于综合医疗保健系统的经认可的独立睡眠障碍中心连续就诊的200例因入睡性失眠前来评估的患者进行回顾性病历审查。
患者的平均年龄（±标准差）为51.1±14.8岁；60%为女性。56%的患者被诊断为抑郁症，38%在就诊时正在接受抗抑郁药治疗，45%符合RLS的临床诊断标准。通过卡方分析或优势比，RLS与抗抑郁药使用或任何特定类别的抗抑郁药使用之间均无统计学关联。接受甲状腺功能减退治疗的患者和服用雌激素的患者与RLS呈正相关；接受β肾上腺素能拮抗剂治疗的患者与RLS呈显著负相关。
尽管有关于使用抗抑郁药导致或加重RLS的传闻报道，但对该问题的系统性研究未能证实两者之间存在关联。
