Machine learning-based prediction of restless legs syndrome using digital phenotypes from wearables and smartphone data.

Restless legs syndrome (RLS) is a relatively common neurosensory disorder that causes an irresistible urge for leg movement. RLS causes sleep disturbances and reduced quality of life, but accurate diagnosis remains challenging owing to the reliance on subjective reporting. This study aimed to propose a predictive machine learning model based on digital phenotypes for RLS diagnosis. Self-reported lifestyle data were integrated via a smartphone application with objective biometric data from wearable devices to obtain 85 features processed based on circadian rhythms. Prediction models used these features to distinguish between the non-RLS (International Restless Legs Study Group Severity Rating Scale [IRLS] score ≤ 10) and RLS symptom groups (10 < IRLS ≤ 20) and between the non-RLS and severe RLS symptom groups (IRLS > 20). The RF model showed the highest performance in predicting the RLS symptom group and XGB model in the severe RLS symptom group. For the RLS symptom group, when using only wearable device data, the AUC, accuracy, precision, recall, and F1 scores were 0.78, 0.70, 0.66, 0.84, and 0.74, respectively, while these scores combining wearable device and application data were 0.86, 0.76, 0.68, 1.00, and 0.81, respectively. For the severe RLS symptom group, when using only wearable device data, XGB achieved AUC, accuracy, precision, recall, and F1 scores of 0.66, 0.84, 0.89, 0.93, and 0.91, respectively, while these scores combining wearable device and application data were 0.70, 0.80, 0.88, 0.90, and 0.89, respectively. Diverse digital phenotypes clinically associated with RLS were processed based on circadian rhythms to demonstrate the potential of digital phenotyping for RLS prediction. Thus, our study establishes early detection and personalized management of RLS.Trial Registration: Clinical Research Information Service (CRIS) KCT0009175 (Registration data: Feb-15-2024) ( https://cris.nih.go.kr/cris/search/detailSearch.do?search_lang=E&focus=reset_12&search_page=M&pageSize=10&page=undefined&seq=26133&status=5&seq_group=26133 ).