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生物威胁治疗的研究策略。

Research strategies for the treatment of biothreats.

作者信息

Cherwonogrodzky John W

机构信息

Department of National Defence, Defence R&D Canada (DRDC Suffield), Chemical and Biological Defence Section, Box 4000 Station Main, Medicine Hat, Alberta T1A 8K6, Canada.

出版信息

Curr Opin Pharmacol. 2005 Oct;5(5):465-72. doi: 10.1016/j.coph.2005.04.011.

Abstract

Whether it is a layperson in the street or a politician in the Senate, there is widespread fear over the consequences of biothreats. In response to these fears, a wide range of treatments has been developed. These include antibiotics (conventional and unconventional uses), nucleic acids (analogues, antisense, ribozymes and DNAzymes), immunomodulators, antibodies, bacteriophage therapy and micro-encapsulation. Furthermore, there are often additional benefits when these therapeutics are used in combination, rather than alone. Although there has been much investment in therapeutics against a terrorist threat for reasons of national security, there are likely to be far greater benefits and applications on domestic and world health.

摘要

无论是街头的普通民众还是参议院的政治家,都对生物威胁的后果深感恐惧。针对这些担忧,人们研发出了各种各样的治疗方法。这些方法包括抗生素(传统和非传统用途)、核酸(类似物、反义核酸、核酶和脱氧核酶)、免疫调节剂、抗体、噬菌体疗法和微囊化技术。此外,这些治疗方法联合使用时往往会带来额外的益处,而不仅仅是单独使用。尽管出于国家安全考虑,在针对恐怖主义威胁的治疗方法上投入了大量资金,但在国内和全球健康方面可能会有更大的益处和应用。

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