Nouws Henri P A, Delerue-Matos Cristina, Barros Aquiles A, Rodrigues José A
REQUIMTE, Instituto Superior de Engenharia do Porto, Portugal.
J Pharm Biomed Anal. 2005 Sep 1;39(1-2):290-3. doi: 10.1016/j.jpba.2005.02.040.
A flow injection square wave cathodic stripping voltammetric method has been developed for the determination of sertraline in a pharmaceutical preparation. The method shows linearity between peak current intensity and sertraline concentration for the interval between 0.20 x 10(-6) and 1.20 x 10(-6) mol L(-1). Limits of detection and quantification were found to be 1.5 x 10(-7) and 5.0 x 10 (-7) mol L(-1), respectively. Up to 70 samples per hour can be analysed with a good precision (R.S.D. = 2.5%). The proposed method was successfully applied to the determination of sertraline in a commercial product. In the voltammetric determination of sertraline in flow, a high sample rate is obtained at reduced costs, opening the possibility to compete with the chromatographic methods generally used for this analysis.
