雌性Wistar肥胖大鼠下丘脑内免疫反应性促肾上腺皮质激素释放激素水平

Immunoreactive corticotropin-releasing hormone levels in the hypothalamus of female Wistar fatty rats.

作者信息

Fukushima M, Nakai Y, Tsukada T, Naito Y, Nakaishi S, Tominaga T, Murakami N, Kawamura H, Fukata J, Ikeda H

机构信息

Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.

出版信息

Neurosci Lett. 1992 Apr 27;138(2):245-8. doi: 10.1016/0304-3940(92)90925-w.

DOI:10.1016/0304-3940(92)90925-w

PMID:1608536

Abstract

We have studied immunoreactive corticotropin-releasing hormone (CRH) levels in the hypothalamus of female Wistar fatty rats, a strain with the fa gene transferred from the Zucker rat to the Wistar Kyoto rat, in an attempt to understand the role of CRH in the development of obesity. A study was conducted with 5-week- and 12-week-old female Wistar fatty rats and lean littermates. There was no significant difference in hypothalamic CRH levels between lean and obese rats at the age of 5 weeks (1887 +/- 99.6 vs. 1767 +/- 124 pg/tissue; mean +/- S.E.M.). Hypothalamic CRH immunoreactivities, however, were significantly lower in 12-week-old obese rats (2361 +/- 132 pg/tissue) than those in lean littermates (2992 +/- 118 pg/tissue; P less than 0.05). The difference of CRH contents between the lean and obese group becomes apparent as they grow up and develop obesity.

摘要

我们研究了雌性Wistar肥胖大鼠下丘脑免疫反应性促肾上腺皮质激素释放激素（CRH）水平，该品系是将fa基因从Zucker大鼠转移至Wistar Kyoto大鼠而培育出的，旨在了解CRH在肥胖发生发展中的作用。对5周龄和12周龄的雌性Wistar肥胖大鼠及其瘦的同窝仔鼠进行了研究。5周龄时，瘦鼠和肥胖鼠下丘脑CRH水平无显著差异（分别为1887±99.6和1767±124 pg/组织；平均值±标准误）。然而，12周龄肥胖大鼠下丘脑CRH免疫反应性（2361±132 pg/组织）显著低于其瘦的同窝仔鼠（2992±118 pg/组织；P<0.05）。随着瘦鼠和肥胖鼠的成长及肥胖的发展，两组间CRH含量的差异变得明显。