遗传性肥胖的 Zucker 大鼠离散下丘脑核团中免疫反应性促肾上腺皮质激素释放激素水平

Immunoreactive corticotropin-releasing hormone levels in discrete hypothalamic nuclei of genetically obese Zucker rats.

作者信息

Nakaishi S, Nakai Y, Fukata J, Naito Y, Usui T, Fukushima M, Jingami H, Nakao K, Imura H

机构信息

Department of Internal Medicine, Kyoto University School of Medicine, Japan.

出版信息

Neurosci Lett. 1993 Sep 3;159(1-2):29-31. doi: 10.1016/0304-3940(93)90790-r.

DOI:10.1016/0304-3940(93)90790-r

PMID:8264973

Abstract

The levels of immunoreactive corticotropin-releasing hormone (ir-CRH) were measured in discrete hypothalamic nuclei and the median eminence of obese Zucker rats and their lean littermates. More than 90% of total hypothalamic ir-CRH was detected in the median eminence in both obese and lean rats. Though ir-CRH levels in the paraventricular nucleus of obese rats tended to be lower than those of their lean littermates, no significant difference of ir-CRH levels was observed in any hypothalamic nuclei studied between obese and lean rats. However, ir-CRH levels in the median eminence of obese rats were significantly lower than those of their lean littermates (5263 +/- 438 pg/tissue vs. 7050 +/- 473 pg/tissue, P < 0.05). These results suggest that the hypoactive hypothalamic CRH tonus would play some role in the phenotypic expression of obesity in the genetically obese Zucker rats.

摘要

在肥胖的 Zucker 大鼠及其瘦的同窝仔鼠的离散下丘脑核团和正中隆起中测量了免疫反应性促肾上腺皮质激素释放激素（ir-CRH）的水平。在肥胖和瘦大鼠中，超过 90% 的下丘脑总 ir-CRH 在下丘脑正中隆起中被检测到。尽管肥胖大鼠室旁核中的 ir-CRH 水平倾向于低于其瘦的同窝仔鼠，但在肥胖和瘦大鼠之间研究的任何下丘脑核团中，未观察到 ir-CRH 水平有显著差异。然而，肥胖大鼠正中隆起中的 ir-CRH 水平显著低于其瘦的同窝仔鼠（5263±438 pg/组织 vs. 7050±473 pg/组织，P<0.05）。这些结果表明，下丘脑 CRH 张力低下在遗传性肥胖 Zucker 大鼠肥胖表型的表达中可能起一定作用。