Singh I, Lazo O
Department of Pediatrics, Medical University of South Carolina, Charleston 29425.
Neurosci Lett. 1992 Apr 27;138(2):283-6. doi: 10.1016/0304-3940(92)90934-y.
Peroxisomal activities were examined in liver and brain of lactating neonatal rats of mothers maintained on ciprofibrate, a peroxisomal proliferator. The activities of DHAP-acyltransferase, alkyl-DHAP synthetase and the beta-oxidation of palmitic and lignoceric acids increased in brain by 3.9, 2.2, 4.3 and 3.2 fold and in liver by 3.2, 2.6, 6.2 and 2.5 fold, respectively, of lactating pups from mothers on ciprofibrate diet as compared to controls. Ciprofibrate treatment increased the peroxisomal enzyme activities in both brain and liver of lactating neonatal rats demonstrating that ciprofibrate or its metabolite(s) transmitted through the mother's milk can effectively induce peroxisomal proliferation.
在以过氧化物酶体增殖剂环丙贝特喂养的哺乳期新生大鼠的母亲的肝脏和大脑中检测过氧化物酶体活性。与对照组相比，环丙贝特饮食喂养的母亲所生哺乳期幼崽的大脑中，二羟丙酮磷酸酰基转移酶、烷基二羟丙酮磷酸合成酶的活性以及棕榈酸和木蜡酸的β-氧化分别增加了3.9倍、2.2倍、4.3倍和3.2倍；在肝脏中分别增加了3.2倍、2.6倍、6.2倍和2.5倍。环丙贝特处理增加了哺乳期新生大鼠大脑和肝脏中的过氧化物酶体酶活性，表明通过母乳传递的环丙贝特或其代谢产物能够有效诱导过氧化物酶体增殖。
