在有血清和无血清情况下，阻止白色念珠菌形成芽管所需的法尼醇浓度。
Farnesol concentrations required to block germ tube formation in Candida albicans in the presence and absence of serum.
作者信息
Mosel Daniel D, Dumitru Raluca, Hornby Jacob M, Atkin Audrey L, Nickerson Kenneth W
机构信息
School of Biological Sciences, University of Nebraska, Lincoln, NE 68588-0666, USA.
出版信息
Appl Environ Microbiol. 2005 Aug;71(8):4938-40. doi: 10.1128/AEM.71.8.4938-4940.2005.
Abstract
Concentrations of (E,E)-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 microM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 microM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.
摘要
通过使用六种已知可触发芽管形成的不同条件，测定了抑制白色念珠菌菌株A72和SC5314芽管形成所需的（E,E）-法尼醇浓度。对于特定培养基，1至2微摩尔的法尼醇就足够了。然而，当血清浓度为2%至20%时，则需要高达250微摩尔的法尼醇。法尼醇可阻止芽管形成，但不会阻止现有芽管的伸长。
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