L-抗坏血酸-2-磷酸酯可增强培养的兔角膜细胞中I型和III型胶原蛋白肽的生成。
L-ascorbic acid 2-phosphate enhances the production of type I and type III collagen peptides in cultured rabbit keratocytes.
作者信息
Saika S, Uenoyama K, Hiroi K, Ooshima A
机构信息
Department of Ophthalmology, Wakayama Medical College, Japan.
出版信息
Ophthalmic Res. 1992;24(2):68-72. doi: 10.1159/000267149.
We studied the effect of L-ascorbic acid 2-phosphate (P-Asc), a long-acting phosphate derivative of L-ascorbic acid, on the production and secretion of type I and type III collagen peptides in cultured rabbit keratocytes using immunohistochemistry and enzyme immunoassay. P-Asc enhanced production and secretion of these collagen peptides. Our observations support a therapeutic role for P-Asc in the repair of corneal stromal damage such as caused by corneal chemical burn.
我们使用免疫组织化学和酶免疫测定法，研究了L-抗坏血酸2-磷酸酯（P-Asc）（L-抗坏血酸的一种长效磷酸酯衍生物）对培养的兔角膜细胞中I型和III型胶原肽产生及分泌的影响。P-Asc增强了这些胶原肽的产生和分泌。我们的观察结果支持P-Asc在修复如角膜化学烧伤所引起的角膜基质损伤中具有治疗作用。
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