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Berberine inhibits arylamine N-acetyltransferase activity and gene expression in Salmonella typhi.

作者信息

Wu Lii-Tzu, Tsou Mei-Fen, Ho Chin-Chin, Chuang Jing-Yuan, Kuo Hsiu-Maan, Chung Jing-Gung

机构信息

Department of Microbiology, China Medical University, Taichung, Taiwan.

出版信息

Curr Microbiol. 2005 Oct;51(4):255-61. doi: 10.1007/s00284-005-4569-7. Epub 2005 Aug 2.

DOI:10.1007/s00284-005-4569-7
PMID:16086103
Abstract

The effects of berberine on growth, arylamine N-acetyltransferase (NAT) activity, and gene expression in Salmonella Typhi (Typhi) were described. The growth inhibition of Typhi was determined by measuring absorbance by optical density (OD at 650 nm). The NAT activity was determined by measuring the levels of 2-aminofluorene (AF) and N-acetyl-2-aminofluorene (AAF) by high-performance liquid chromatography. The results demonstrated that 24-h berberine treatment decreased bacteria growth and amounts of AAF in Typhi. Western blotting and flow cytometry were used for examining the levels of NAT after bacteria were cotreated with or without various concentrations of berberine, and results indicated that berberine decreased the levels of NAT in Typhi. Polymerase chain reaction was used for examining the gene expression of NAT (mRNA NAT), and results indicated that berberine affects mRNA NAT1 expression in Typhi.

摘要

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本文引用的文献

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The anti-inflammatory potential of berberine in vitro and in vivo.黄连素在体外和体内的抗炎潜力。
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Peroxynitrite irreversibly inactivates the human xenobiotic-metabolizing enzyme arylamine N-acetyltransferase 1 (NAT1) in human breast cancer cells: a cellular and mechanistic study.
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Evaluation of Drugs with Therapeutic Potential for Susceptibility of Neisseria Gonorrhoeae Isolates from 8 Provinces in China from 2018.2018年中国8个省份淋病奈瑟菌分离株对具有治疗潜力药物的敏感性评估
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