五种植物细胞悬浮培养物对α-山道年的生物转化

Biotransformation of alpha-santonin by cell suspension cultures of five plants.

作者信息

Yang Lin, Dai Jungui, Sakai Junichi, Ando Masayoshi

机构信息

College of Life and Environmental Sciences, The Central University for Nationalities, 100081, Beijing, P.R. China.

出版信息

Biotechnol Lett. 2005 Jun;27(11):793-7. doi: 10.1007/s10529-005-5800-0.

DOI:10.1007/s10529-005-5800-0

PMID:16086262

Abstract

Cell suspension cultures of five plants (Catharanthus roseus, Ginkgo biloba, Platycodon grandiflorum, Taxus cuspidata, Phytolacca asinosa) were employed to bioconvert the eudesmanolide compound, alpha-santonin. Reactions occurring were hydroxylation (C-1, C-11 and C-15), reduction of the double bond [1(2) or 3(4)], rearrangment of the eudesmanolide skeleton to a guaianolide skeleton and lactone-ring hydrolysis. Four new compounds were identified.

摘要

利用五种植物（长春花、银杏、桔梗、东北红豆杉、商陆）的细胞悬浮培养物对桉叶烷型倍半萜内酯化合物α-山道年进行生物转化。发生的反应包括羟基化（C-1、C-11和C-15）、双键[1(2)或3(4)]还原、桉叶烷型倍半萜内酯骨架重排为愈创木烷型倍半萜内酯骨架以及内酯环水解。鉴定出了四种新化合物。