Foti Maria, Ricciardi-Castagnoli Paola
Department of Biotechnology and Bioscience, University of Milano-Bicocca, Piazza della Scienza 2, Milan, Italy.
Trends Mol Med. 2005 Sep;11(9):394-6. doi: 10.1016/j.molmed.2005.07.001.
The mucosal immune system is the first line of defence against bacterial and viral infections and is crucial in maintaining mucosal homeostasis. In the gut, mucosal dendritic cells offer an alternative pathway to epithelial cells for antigen uptake, to initiate antigen-specific immune responses. It has recently been shown that lamina propria dendritic cells of the small intestine actively sample gut bacteria through the formation of transepithelial dendrites by a mechanism that is dependent on the expression of the chemokine receptor CX3CR1.
黏膜免疫系统是抵御细菌和病毒感染的第一道防线，在维持黏膜内环境稳定方面至关重要。在肠道中，黏膜树突状细胞为上皮细胞提供了一条摄取抗原的替代途径，以启动抗原特异性免疫反应。最近的研究表明，小肠固有层树突状细胞通过一种依赖于趋化因子受体CX3CR1表达的机制，通过形成跨上皮树突来主动摄取肠道细菌。
