Niedergang Florence, Kweon Mi-Na
Département de Biologie Cellulaire, Institut Cochin, CNRS UMR8104, INSERM U567, Université Paris 5, Paris, France.
Trends Microbiol. 2005 Oct;13(10):485-90. doi: 10.1016/j.tim.2005.08.001.
The mucosa represents a large surface of the human body that is in contact with the external environment. Mucosal tissues are colonized by an extremely dense and diverse micro flora of commensal bacteria, which compete with the growth of pathogenic strains. The mucosal sites continuously sample foreign material via specific cells, such as M cells and dendritic cells. Many new ways of antigen uptake have been described recently, especially by M cells and dendritic cells in the intestine. Depending on various factors, antigen presentation in the mucosa can lead to tolerance or initiation of an immune response. Mucosal vaccine strategies will certainly require eliciting specific antigen uptake because this initial step has a crucial role in controlling the outcome of immune responses.
黏膜是人体与外部环境接触的一个大表面。黏膜组织定植着极其密集和多样的共生细菌微生态群，它们与致病菌株的生长相互竞争。黏膜部位通过特定细胞，如M细胞和树突状细胞，持续对异物进行取样。最近已经描述了许多新的抗原摄取方式，尤其是肠道中的M细胞和树突状细胞的摄取方式。根据各种因素，黏膜中的抗原呈递可导致免疫耐受或引发免疫反应。黏膜疫苗策略肯定需要引发特异性抗原摄取，因为这一初始步骤在控制免疫反应结果方面起着关键作用。
