Brumfield Anne M, Andrew Michael E
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA.
Physiol Meas. 2005 Oct;26(5):599-608. doi: 10.1088/0967-3334/26/5/003. Epub 2005 May 31.
The resting peripheral volume pulse wave of 44 subjects within three age categories (30-39, 40-49, 50) has been characterized using a novel algorithm for the automated determination of a mean pulse function. The contour of this resting mean pulse has been analyzed with regard to its systolic and diastolic characteristics. Previously described indices of arterial stiffness and viscoelasticity have been investigated for age-dependent variations associated with arterial mechanical properties. Measures of the minimum rise time (MRT) and the stiffness index (SI) demonstrated strong correlations with age and each other, although their derivations are unrelated. While significant correlations existed (|r| = 0.50-0.78, p < or = 0.002), pairwise comparisons between the right and left hands did not demonstrate significant differences for the minimum rise time parameter; however, the stiffness index was significantly lower in the left hand versus the right (p = 0.009). With regard to age, the youngest age group had significantly lower MRT and SI values than the two older groups. For these data, this was only demonstrated in parameters calculated for the right hand because of higher variability within age groups for the left hand. A normalized average mean pulse for each age group was determined which visually illustrated the contour changes associated with the MRT and SI parameters that occur in both the systolic and diastolic portions of the pulse. The finding that differences between the age groups were significantly more evident for the right hand suggests that the physical site for such testing may be an important consideration. This study provides further evidence regarding the merit of using contour analysis when assessing the peripheral volume pulse and the importance of establishing ageing indices for such analysis.
使用一种用于自动确定平均脉搏函数的新算法，对三个年龄组（30 - 39岁、40 - 49岁、50岁）的44名受试者的静息外周容积脉搏波进行了特征描述。已针对其收缩期和舒张期特征分析了这种静息平均脉搏的轮廓。研究了先前描述的动脉僵硬度和粘弹性指标与动脉力学特性相关的年龄依赖性变化。最小上升时间（MRT）和僵硬度指数（SI）的测量值显示出与年龄以及彼此之间有很强的相关性，尽管它们的推导无关。虽然存在显著相关性（|r| = 0.50 - 0.78，p≤0.002），但左右手之间的成对比较未显示出最小上升时间参数有显著差异；然而，左手的僵硬度指数显著低于右手（p = 0.009）。关于年龄，最年轻的年龄组的MRT和SI值明显低于两个较年长的组。对于这些数据，由于左手年龄组内变异性较高，仅在右手计算的参数中得到了证明。确定了每个年龄组的归一化平均平均脉搏，直观地展示了与脉搏收缩期和舒张期部分中MRT和SI参数相关的轮廓变化。年龄组之间的差异在右手中明显更明显这一发现表明，进行此类测试的身体部位可能是一个重要的考虑因素。本研究为评估外周容积脉搏时使用轮廓分析的优点以及为此类分析建立老化指数的重要性提供了进一步的证据。
