Joshi Dipesh, Naidu Pattipati S, Singh Amanpreet, Kulkarni Shrinivas K
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, India.
Pharmacology. 2005 Oct;75(2):93-7. doi: 10.1159/000087189. Epub 2005 Jul 25.
Chronic administration of triazolam (0.25 mg/kg/day, i.p.) on days 1-8 and its withdrawal produced an anxiogenic reaction in mice as assessed in the mirrored-chamber test. Daily administration of bupropion (2 or 5 mg/kg, i.p.) prior to triazolam for 8 days prevented withdrawal-induced anxiety in mice. Triazolam withdrawal also induced a significant increase in the locomotor activity of mice indicating an anxiogenic response. Daily administration of bupropion (2 or 5 mg/kg) prior to triazolam for 8 days also prevented withdrawal-induced increased locomotor activity. In conclusion, chronic administration of bupropion (2 and 5 mg/kg) exhibited a significant protection against triazolam withdrawal-induced anxiety and hyperlocomotor activity in mice. The result suggests the protective effect of bupropion in the management of triazolam withdrawal reactions.
在第1 - 8天腹腔注射三唑仑（0.25毫克/千克/天）并停药后，通过镜像箱试验评估发现，这在小鼠中产生了致焦虑反应。在三唑仑给药前8天每天腹腔注射安非他酮（2或5毫克/千克）可预防小鼠停药引起的焦虑。三唑仑停药还导致小鼠运动活动显著增加，表明存在致焦虑反应。在三唑仑给药前8天每天注射安非他酮（2或5毫克/千克）也可预防停药引起的运动活动增加。总之，长期给予安非他酮（2和5毫克/千克）对小鼠三唑仑停药引起的焦虑和运动亢进活动具有显著的保护作用。结果表明安非他酮在处理三唑仑停药反应方面具有保护作用。
