Wang Qin, Doerschuk Claire M, Mizgerd Joseph P
Division of Integrative Biology, Department of Pediatrics, Rainbow Babies and Children's Hospital and Case Western Reserve University, Cleveland, Ohio, USA.
Semin Respir Crit Care Med. 2004 Feb;25(1):33-41. doi: 10.1055/s-2004-822303.
Neutrophils are an important component of innate immunity in the lungs. During bacterial pneumonia, neutrophils are recruited from the capillaries of the pulmonary circulation in the gas-exchanging regions of the lungs. This process requires the coordinated activation of many cells within the lungs, including neutrophils and capillary endothelial cells. Cellular activation during innate immune responses is mediated in part by tumor necrosis factor-alpha (TNF-alpha) and interleukin (IL)-1-initiated signaling through their receptors, activation of nuclear factor kappa B (NF-kappaB) and downstream gene transcription, endothelial cell signaling initiated by neutrophil adherence to intercellular adhesion molecule (ICAM)-1, and binding of leukocyte adhesion molecules to cellular and matrix ligands. These events are essential to effective host defense during pneumonia.
中性粒细胞是肺部固有免疫的重要组成部分。在细菌性肺炎期间，中性粒细胞从肺气体交换区域的肺循环毛细血管中募集而来。这一过程需要肺内许多细胞的协同激活，包括中性粒细胞和毛细血管内皮细胞。固有免疫反应期间的细胞激活部分是由肿瘤坏死因子-α（TNF-α）和白细胞介素（IL）-1通过其受体启动信号传导、激活核因子κB（NF-κB）和下游基因转录、中性粒细胞黏附于细胞间黏附分子（ICAM）-1引发的内皮细胞信号传导以及白细胞黏附分子与细胞和基质配体的结合介导的。这些事件对于肺炎期间有效的宿主防御至关重要。
