Macfarlan R I, Ceredig R, White D O
Infect Immun. 1979 Dec;26(3):832-6. doi: 10.1128/iai.26.3.832-836.1979.
Natural killer (NK) cells are rapidly elicited in the spleen and peritoneal cavity of mice inoculated intravenously or intraperitoneally with live Kunjin virus, and more slowly in the peritoneal cavity of mice inoculated intraperitoneally with Formalin-inactivated Corynebacterium parvum. NK cells induced by either agent display cytotoxicity for a similar spectrum of syngeneic, allogeneic, and xenogeneic cultured cell lines. By contrast, the cells occurring naturally in the spleen of congenitally athymic (nude) mice show substantially lower NK activity and are cytotoxic for a more restricted range of target cell lines. The distinction suggests that there may be more than one type of NK cell or that activation enhances the cytotoxicity and perhaps broadens the range of target specificity of endogenous NK cells.
将活的库京病毒静脉内或腹腔内接种到小鼠体内后，自然杀伤（NK）细胞会在小鼠的脾脏和腹腔中迅速被激发；而将福尔马林灭活的微小棒状杆菌腹腔内接种到小鼠体内后，NK细胞在腹腔中的激发则较为缓慢。由这两种制剂诱导产生的NK细胞对同基因、异基因和异种培养细胞系的相似谱显示出细胞毒性。相比之下，先天性无胸腺（裸）小鼠脾脏中自然存在的细胞显示出明显较低的NK活性，并且对更有限范围的靶细胞系具有细胞毒性。这种差异表明可能存在不止一种类型的NK细胞，或者激活会增强细胞毒性，并且可能拓宽内源性NK细胞的靶标特异性范围。
