Haller O, Kiessling R, Orn A, Wigzell H
J Exp Med. 1977 May 1;145(5):1411-6. doi: 10.1084/jem.145.5.1411.
Generation of natural killer (NK) cells in spleens from radiation chimeras produced between pairs of histocompatible 'high' and 'low' NK-reactive mouse strains has been investigated. Spleen cells of high-reactive recipients reconstituted with bone marrow from low-reactive mice were found to be low reactive. Conversely, spleen cells of low mice grafted with bone marrow or fetal liver cells from high donors were high reactive. Similarly, the age-related changes of NK activity were shown to be expressed at the bone marrow precursor cell level. These results indicate that the generation of natural killer cells is an inborn and autonomous function of the bone marrow and does not depend on the genotype or other influences of the host environment.
对由组织相容性“高”和“低”自然杀伤（NK）反应性小鼠品系配对产生的辐射嵌合体脾脏中NK细胞的生成进行了研究。发现用低反应性小鼠的骨髓重建的高反应性受体的脾细胞反应性较低。相反，移植了来自高反应性供体的骨髓或胎肝细胞的低反应性小鼠的脾细胞反应性较高。同样，NK活性的年龄相关变化显示在骨髓前体细胞水平上表达。这些结果表明，自然杀伤细胞的生成是骨髓的一种先天自主功能，不依赖于宿主环境的基因型或其他影响。
